The case-based book provides an up-to-date overview of clinical management of gastrointestinal stromal tumors (GISTs). Firstly, surgical management of GISTs by laparoscope, endoscope, robot, and laparoscope combined endoscope is introduced. Following chapters discuss preoperative treatment of GISTs and management of uncommon types of GISTs in different sites. Then targeted therapy for GISTs and authors’ exploration in therapy for advanced GISTs is presented. Last but not least, management of GISTS misdiagnosed is elucidated. With typical cases and detailed analysis, this book is a useful reference for gastrointestinal and general surgeons, as well as practitioners who are interested in this challenging malignancy.